Actim® PROM

Reports PROM reliably, even for samples containing blood.

Superior accuracy unaffected by blood

  • Vaginal bleeding complicates reliable diagnostics of Premature Rupture of Fetal Membranes (PROM)
  • Up to 20% of women with suspected PROM experience bleeding
  • Actim PROM is the only PROM test not affected by blood, giving accurate results for all expecting mothers

Why it works?

  • The monoclonal antibodies of Actim PROM specifically detect the amniotic isoforms of insulin-like growth factor protein (IGFBP-1)
  • The wide detection range of Actim PROM covers all clinically relevant concentrations of IGFBP-1 from the smallest membrane microruptures to larger volumes of amniotic fluid
  • The detection limit of Actim PROM excludes IGFBP-1 concentrations found in maternal blood, further increasing the specificity of the test for amniotic IGFBP-1

Actim PROM test reports PROM accurately, even for samples containing blood. The presence of blood does not affect the visual interpretation of the test at the 5-minute time-point.


  • Rutanen et al., 1996. Evaluation of a rapid strip test for insulin-like growth factor binding protein-1 in the diagnosis of ruptured fetal membranes.
    Clin Chim Acta (1996) 253:91-101.
  • Kubota et al., 1998. Evaluation of insulin-like growth factor binding protein-1 as a diagnostic tool for rupture of the membranes.
    J Obstet Gynecol Res (1998) 24:411-417.
  • Guibourdenche et al., 1999. Rapid detection of insulin-like growth factor-binding protein-1 and foetal fibronectin in cervico-vaginal secretions to diagnose premature membrane rupture.
    Ann Clin Biochem (1999) 36:388-390.
  • Erdemoglu and Mungan, 2004. Significance of detecting insulin-like growth factor binding protein-1 in cervicovaginal secretions: Comparison with nitrazine test and amniotic fluid volume assessment.
    Acta Obstet Gynecol Scand (2004) 83:622-626.
  • Novikova et al., (2007). Verification of premature rupture of membranes using the express test Actim PROM.
    Voprosy ginekologii, akusherstva i perinatologii (Problems of Gynecology, Obstetrics and Perinatology) 6.102‐5.
  • Kallioniemi et al., 2014. Usefulness of the insulin-like growth factor binding protein-1 bedside test for ruptured fetal membranes.
    Obstet Gynecol Scand (2014) 93:1282-1289.
  • Kanto et al., 2018. Comparison of eight commercial PROM tests: Actim® PROM is the only test not reporting PROM false positives for maternal sera, and not exhibiting hook effect.
    Oral presentation at European Congress of Perinatal Medicine at St. Petersburg, Russia, 8th Sep 2018